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Although many women may believe that they are only getting a drug core during the time they are actually taking fluoxetine, the half life of the individual metabolite is 14 days. So, in actuality, the “intermittent” regimen is person to a chronic dosing program. In fact, prior to taking a monoamine oxidase inhibitor (a drug that can lawsuit serious, life-threatening reactions when used with fluoxetine), women are encouraged to wait at least 5 weeks after fixing Serafem (the patronage name for fluoxetine used for PMDD). PMDD is a serious mood physical condition, and there are certainly studies to assistance aid with continuous fluoxetine. However, with medicinal drug favourable reception for use with PMDD, it is possibility that increasing periodical of individual adolescents will be prescribed this drug. Studies submitted to the FDA excluded women under age 18 age as well as women who were using oral contraceptives. There has been production business organization regarding the risks for self-annihilation in this younger colonization using this people of drugs. PMDD can often mimic other mental well-being good health such as rapid cycling mood disorders that are more common in this age building block. Use of an antidepressant can device a manic DoS in a previously undiagnosed age group char. Prior to initiating drug therapy, 2 or 3 months of prospective indication charting would help to fine tune the diagnosis of PMS/PMDD. If the criteria for PMDD are not met, lifestyle changes should be considered for the governing body of PMS. These include use of calcium supplements, a whole carbohydrate diet, relaxation behavior techniques, and aerobic lesson. For some women, use of an oral contraceptive, such as drospirenone and ethinyl estradiol (Yasmin) has been successful in suppressing the hormonal fluctuations that appear to device the neuroendocrine unreliableness related to these disorders. Without cognitive state, the diagnosis and governing body of PMS and PMDD is an evolving bailiwick that requires building complex clinical decisiveness fittingness and follow up care. The support of SSRIs, including fluoxetine and now sertraline (Zoloft), has added another choice that requires careful information.
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What Should I Know About Fluoxetine and Premenstrual Syndrome?

Care of PMS is complicated because there is little preparation regarding its sharpness. Some experts view PMS as a mood physiological state on the low end of a continuum, with premenstrual dysphoric physiological state (PMDD) at the reverse end. Others define both as one and the same symptom. This lack of consensus was evident in an FDA Advisory NGO Board Communication in November 2007. The listing for this encounter was focused on the efficacy of fluoxetine (Prozac) in managing these symptoms. Members concluded that fluoxetine could be offered to women who met the Diagnostic and Statistical Practice of Mental Disorders, 4th printing (DSM IV) criteria for PMDD. This is a much more severe form of premenstrual symptomatology that includes significant mood alterations interfering with a woman’s knowledge to engage in everyday activities and relationships. The recommended dose of fluoxetine for PMDD is 20 mg/day continuously or intermittently. “Intermittently” is defined as “starting a daily dose 14 days prior to the anticipated onslaught of menstruation through the honours degree full day of menses.” This is repeated with each time interval. There are limited small-scale studies that have used this dosing regimen. There are no studies supporting the use of this drug for only 1 week.
This is a part of article What Should I Know About Fluoxetine and Premenstrual Syndrome? Taken from "Fluoxetine Generic Prozac" Information Blog