What Should I Know About Fluoxetine and Premenstrual Syndrome?

Care of PMS is complicated because there is little preparation regarding its sharpness. Some experts view PMS as a mood physiological state on the low end of a continuum, with premenstrual dysphoric physiological state (PMDD) at the reverse end. Others define both as one and the same symptom. This lack of consensus was evident in an FDA Advisory NGO Board Communication in November 2007. The listing for this encounter was focused on the efficacy of fluoxetine (Prozac) in managing these symptoms. Members concluded that fluoxetine could be offered to women who met the Diagnostic and Statistical Practice of Mental Disorders, 4th printing (DSM IV) criteria for PMDD. This is a much more severe form of premenstrual symptomatology that includes significant mood alterations interfering with a woman’s knowledge to engage in everyday activities and relationships. The recommended dose of fluoxetine for PMDD is 20 mg/day continuously or intermittently. “Intermittently” is defined as “starting a daily dose 14 days prior to the anticipated onslaught of menstruation through the honours degree full day of menses.” This is repeated with each time interval. There are limited small-scale studies that have used this dosing regimen. There are no studies supporting the use of this drug for only 1 week.
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