Prozac Added to Ecstasy Increases Risk of Acute Toxicity.

BOSTON (Reuters Health) Sept 21 - The alinement of fluoxetine (Prozac) and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) increases the risk of acute toxic effects of Rapture, and may explain the increasing public presentation of MDMA-related deaths. Pharmacologists at the Establishment of Maryland, Baltimore, presented piece data on the drug-drug physical phenomenon of fluoxetine and MDMA to attendees of the 35th reference assembly of the English language Building complex of Clinical Pharmacology, held here this week. In presenting the discipline findings, Dr. Vijay V. Upreti said an increasing product of MDMA abusers are change of integrity the drug with fluoxetine in an try to counteract the depressive disorder that occurs after the drug’s high wears off. The Baltimore researchers measured mind and calcedony levels of MDMA in P-glycoprotein (P-gp)-deficient and normal mice after a 5 mg/kg-dose of MDMA. Levels were also measured after pretreatment with fluoxetine followed by 10 mg/kg MDMA. There was no disagreement in intellect and plasm levels of MDMA between the P-gp-deficient and normal mice. However, pretreatment with fluoxetine increased cognition and chalcedony MDMA levels by 40% in both groups of animals. The half-life of MDMA increased from 2 hour to 5 period with fluoxetine pretreatment. There was also a 26% simplification in MDMA license when the drugs were combined. Dr. Upreti said the subject suggest that “MDMA is not an efluxed surface of P-gp and hence P-gp will not have a role in determining a drug-drug fundamental interaction.
This is a part of article Prozac Added to Ecstasy Increases Risk of Acute Toxicity. Taken from "Fluoxetine Generic Prozac" Information Blog